Head of Translational Genome Informatics

Job No: GC2061
Location: Darlinghurst

The Garvan Institute is one of Australia’s leading medical research institutions with approximately 500 scientists, students and support staff working in research programs in Cancer, Diabetes & Obesity, Immunology & Inflammation, Genome Informatics, Osteoporosis, and Neuroscience.

The Kinghorn Centre for Clinical Genomics (KCCG) advances the use of genomic information in patient care by employing world-leading DNA analysis technology and expertise in genetics, pathology and bioinformatics. KCCG’s activities are strategically directed to enable rapid translation of genomic research into the clinic and advance the implementation of precision medicine in routine healthcare. Members of our group have both production and research roles, with diverse backgrounds and includes informaticians, software developers, biologists and clinicians. We were among the first three sites worldwide to acquire an Illumina HiSeq X Ten sequencing factory, capable of sequencing 150 whole human genomes every 3 days at a cost of $1000 per genome.


We are now seeking a Head of Translational Genome Informatics to lead a team in advancing the state-of-the-art in whole genome interpretation. The primary specific objectives of the team are: (1) to support specialty disease investigators in the identification of new genetic determinants in rare and genetic diseases where there are no clinically-determinable findings; (2) development of new tools and algorithms to reliably identify and classify regions of the genome that are not interpreted by conventional approaches and could be directly related to disease pathogenicity or disease predisposition; and (3) to develop approaches based on existing scientific literature to enable diagnosis or risk status for complex diseases.

This leadership role will be responsible for coordinating and executing relevant projects and activities within the Translational Genome Informatics group. They will ensure KCCG remains at the forefront of genome interpretation approaches and place emphasis on methodologies that have transformative potential and could be used in clinical practice.


The successful candidate will demonstrate the following key skills and attributes:

  • A PhD in genomics or a related field
  • Strong background in bioinformatics, with at least 10 years of experience
  • Strong expertise in clinical interpretation of genomic data
  • Strong expertise in working with next-generation sequencing data
  • Experience in team building, leadership and collaboration


In return the the Head of the Translational Genomics group will have access to a competitive salary, participation in local and international conferences, and publishing opportunities in a rich interdisciplinary research environment.



Remuneration for this position is competitive and commensurate on experience with additional salary packaging benefits. The position is based at The Kinghorn Cancer Centre, a new joint initiative of the Garvan Institute of Medical Research and St. Vincent’s Hospital, located in inner-city Darlinghurst.

http://kinghorncancercentre.com. The Kinghorn is rapidly developing expertise and large capacity in cancer genomics and informatics and will provide a supportive and exciting environment for the fellow.

For further details, please contact Marcel Dinger by email (m.dinger@garvan.org.au).


How to apply


Please submit your application by visiting our career site: www.garvan.org.au/careers.

In addition to your CV and cover letter, please also provide a link to, or sample of, your existing open source programming work.


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