Are you looking for a fulfilling role that contributes to a broader purpose?
At Garvan, we see the big picture of health and disease. Our research is finding real treatments for the world’s major diseases. We study the interlinked causes from genetics to lifestyle and diet — and we collaborate across the spectrum of health and biology. We harness the information of the genome to predict, diagnose, prevent and treat disease — and realise our vision of a future where everyone lives longer, healthier lives.
Your role in our future
Our laboratory is focussed on identifying new treatment options for osteosarcoma, a cancer of bone. Areas of interest include functionally testing genes identified in genome wide association studies of osteosarcoma risk and survival, investigating the cross talk between tumour and the immune system, determining the role of inflammatory cytokines, and testing immune checkpoint blockade and chemotherapy induced modification of immune response.
We are seeking a highly motivated, hardworking talented Research Assistant who will make a major contribution to our research efforts. This individual will help establish cohorts of mice with radiocarcinogen-induced osteosarcomas and monitor tumour formation to identify genes that modify osteosarcoma growth. They will test therapeutics of interest in preclinical mouse models of osteosarcoma established in the lab. In addition to mouse studies we will validate our results using clinical specimens.
The purpose of this position is to carry out experiments that fulfil the aims of the project, to accurately analyse and interpret experimental results, prepare data in a manner suitable for incorporation in manuscripts for publication.
The key responsibilities include:
- Planning and executing research
- In vivo and in vitro analysis of transgenic and radiocarcinogen mouse models of osteosarcoma using physiological, immunology and molecular based techniques
- Animal husbandry and handling
- Mammalian cell culture, cell fate assays (proliferation, apoptosis), molecular biology techniques (RNA/DNA isolation, qRT-PCR, In situ hybridisation), Immunology based assays (multiparametric flow cytometry), Western blotting and Immunohistochemistry.
- Participate in group discussions
- Aid other group members in developing improved techniques or procedures
- Laboratory maintenance.
You will have the following skills and experience:
- Essential: B.Sc (Hons)/Masters or equivalent in Microbiology, Biochemistry or Pathology with 3+ years laboratory experience.
- Essential: Ability to work well within a research team exemplified by diligence, accountability and collegiality
- Essential: Solid knowledge and experience working within a laboratory environment
- Essential: Experience with cell biology techniques including cell culture, conducting cell-based assays in vitro (i.e. cell counting, drug treatments, proliferation and apoptosis assays)
- Essential: Experience with molecular biology techniques, RNA/DNA isolation, protein extraction, Western blotting, Multiparametric, flow cytometry, desirable Immunohistochemistry
- Essential: Experience with laboratory mice, tumour models (any tumour), highly desirable application of drugs v, and gavage
- Essential: Exceptional communication skills, time management skills and attention to detail.
- Essential: Technical precision when carrying out experiments is critical
- Essential: High quality written and oral communication skills.
- Essential: flexibility and ability to learn new skills.
- Essential: Strong interest in the field of Cancer Research
- Desirable: Experience using Microsoft Word, Excel and FlowJo
How to Apply:
All applications must be submitted via the Garvan Careers site via the link below. Applications from other sites will unfortunately not be considered.
Your application should include:
- A cover letter addressing the selection criteria above
- Your resume including at least 2 referees
- Copies of relevant qualifications / academic transcripts
Only applicants with full working rights in Australia are eligible to apply for this role.
This position will be offered for one year full-time.
We are reviewing applications as we receive them so don't wait to apply!