Research Officer – Transplantation Immunology
The Transplantation Immunology laboratory aims to understand the genetic causes of immunological diseases through genome sequencing and functional analyses and use this knowledge to generate novel transplant therapeutics. These findings can improve outcomes for the patients, their families and other individuals with immune related diseases, as well as extend our understanding of basic immunological processes.
Garvan uses the state-of-the-art genomics technologies to identify candidate genes that may cause immune disease. Bespoke functional experiments in cells and animal models are then used to confirm functional candidate genes and determine mechanisms of disease.
The Research Officer will assist in the identification, investigation and functional characterisation of novel gene variants. The appointee will participate in selection of candidate genetic variants after genome sequencing, and will perform experimental work to assess the implications of the variants on immune cell function.
Reporting to the Laboratory Head, Associate Professor Shane Grey, the key responsibilities include:
- Design and manage own experiments and report and discuss findings back to supervisor
- Regularly attend extra seminar meetings and conferences
- Contribute towards research projects through to authorship of abstracts and publications in journals specific to field
- Develop research-related material for the benefit of collaborators, with appropriate guidance from senior staff, and assist in the design and/or the operation of specialised laboratory and technical equipment or the conduct of advanced research procedures
- Proactively and efficiently manage the administrative functions associated with lab management
- Organise resource and equipment issues
The position will be full-time for 2 years in the first instance and the salary offered is $83,574 pa.
You will have the following key skills and experience:
- PhD in relevant field and 2 years of relevant research experience
- Working knowledge of human genome databases (gnomAD; ENSEMBL)
- Molecular biology skills, e.g. PCR, cloning, mutagenesis, cell transfection, CRISPR, TALEN
- Experience with cell biology, reporter assays, imagining, flow cytometry and other immunoassays (ELISA)
- Zebrafish husbandry and working knowledge of zebrafish models
- Mouse model experience – particularly immune models & physiological monitoring (DEXA; GTT)
- Generation of zebrafish genetic mutants (CRISPR/TALEN) & embryo microinjection
- Imaging (confocal; 3-D rendering; light microscopy and working knowledge of related software)
- Ability to rapidly learn new techniques
- Results-oriented; adaptable approach to answering scientific questions
- Excellent time management and ability to prioritise tasks
- Display innovative and proactive abilities
- Comfortable with moderate decision making
- Possess strong computing skills including bioinformatic analysis
- Previous experience working with flow cytometry
- Expertise/knowledge in the field of immunology
How to Apply
All applications must be submitted via Garvan’s Careers site via the link below. Applications from other sites/channels will unfortunately not be considered.
Please include the following in your application:
- A cover letter
- Your resume including at least 2 referees
- Copies of relevant qualifications / academic transcripts
This position will remain open until 5 April 2019. We are reviewing applications as they are received, as such candidates are encouraged to submit their application as soon as possible.