Bioinformatics Research Assistant - RNA Biology & Plasticity

Job No: GC201820
Location: Darlinghurst, Sydney, NSW

At the Garvan Institute, our research is focused upon understanding the role of genes and molecular and cellular processes in health and disease as the basis for developing future preventions, treatments and cures. Our scientists are researchers who work towards making significant breakthroughs in scientific discovery to positively impact human health.

The Opportunity

We are now seeking a talented Bioinformatician to join the Epitranscriptomics and RNA Dynamics group, which is embedded under the RNA Biology and Plasticity laboratory, led by Professor John Mattick. Depending on the skillset of the applicant, either a Bioinformatics Research Assistant or Bioinformatics Research Officer position will be offered.   

The Epitranscriptomics and RNA Dynamics group has an available position to work on data analysis  and algorithm development from sequencing data produced using Oxford Nanopore Technologies (ONT), using direct RNA sequencing. This novel technology, only released in mid-2017, is a promising cost-effective alternative to Illumina sequencing, which allows to directly detect RNA modifications as the molecules pass through the pore. 

The candidate will also provide bioinformatics support to conduct functional integrative analysis of high-throughput ‘-omics’ datasets (e.g. transcriptomics) generated by high-throughput sequencing platforms, which will be used as orthogonal validation of the data produced using Oxford Nanopore Technologies.

To be successful in this position, you will be an analytical thinker with a strong background in Bioinformatics, proficiency in at least one programming language (C, C++, Python or R), who is motivated by being part of the innovative and dynamic culture of the Garvan Institute. You will be strong collaborator who thrives in a culture of performance and empowerment.

You will also possess the following key skills and attributes:

  • BSc (Hons 1), MSc or BVSc undergraduate degree in Life Sciences, Computer Science, Bioinformatics or similar field.
  • MSc and/or PhD in Bioinformatics, Statistics or Computer Science. MSc/PhD in Molecular Biology or similar field are also encouraged to apply if a strong computational background exists
  • 3 years + experience in Programming, Computer Science and/or Data Analysis.
  • Strong experience and scientific expertise in analysis of high-throughput sequencing data, including RNASeq
  • Excellent analytical and problem-solving skills
  • A capacity for carrying out duties under minimal supervision
  • Drive and commitment to produce high quality experimental outcomes
  • Ability to contribute to preparation of written reports and oral presentations

About the Research:

Direct RNA sequencing using Oxford Nanopore Technologies will likely revolutionise our ability to map additional RNA modifications, allowing us to understand the functional roles of the battery of RNA modifications that decorate our RNAs, as well as comprehend how and why their dysregulation leads to numerous human diseases.

How to apply

All applications MUST be submitted via Garvan’s careers website: 

In addition to your CV and cover letter please also attach relevant qualifications.

Closing Date

This role will remain open until filled.

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